What Is LipoVITA® C Xtend?
LipoVITA® C Xtend is an advanced liposomal system in which vitamin C is encapsulated within nanosized lipid vesicles modified with a polymeric surface.
Role of the liposome: Protects vitamin C from oxidation and degradation, enabling controlled release and higher bioavailability.
Role of the polymeric surface: Improves stability, enhances interaction with the stratum corneum, and prolongs retention in skin layers.
This dual design maximizes vitamin C’s antioxidant performance while ensuring effective delivery to target skin cells.
Effects on Skin Hydration and Barrier Properties:
1. Moisture Retention
Encapsulation provides sustained delivery of vitamin C, supporting hydration by strengthening the barrier and reducing transepidermal water loss.
2. Barrier Repair & Elasticity
By stimulating fibroblasts and collagen synthesis, LipoVITA® C Xtend improves skin firmness, elasticity, and structural integrity.
3. Enhanced Penetration
The polymer-modified vesicles modulate the stratum corneum lipids, allowing vitamin C and co-encapsulated antioxidants to penetrate efficiently and remain longer in epidermal and dermal layers.
Figure: The mean percentage of the viable HSF cells after treatment with different doses of LipoVITA® C for 48h
Research Insights
Hydration advantage: In vitro and ex vivo tests show liposomal vitamin C systems maintain superior hydration over free vitamin C.
Skin feel / texture: Users note better smoothness, suppleness, and less tightness, suggestive of barrier enhancement.
Penetration efficiency: Studies demonstrate higher uptake and retention in skin layers compared to non-encapsulated vitamin C forms.
Stability: Surface-modified liposomes resist aggregation, oxidation, and stress better than conventional liposomes under storage and UV exposure.
Concussion
LipoVITA® C Xtend represents a next-generation delivery system that combines the stabilizing power of a polymer-modified liposome with the antioxidant benefits of vitamin C. By protecting the molecule from oxidation and enhancing its penetration into the skin, this system ensures longer-lasting hydration, improved barrier function, and greater elasticity. Its ability to deliver vitamin C more efficiently into epidermal and dermal layers translates into visible improvements in brightness, firmness, and overall skin vitality, while offering superior stability compared to conventional formulations.
Reference
Gitlesen, E., McGinn, S., Mohamed, N., Saadani, A., & Hagagy, R. H. (2025). Modified Polymeric Surface Liposomal Vitamin C as an Advanced and Effective Formulation in Topical Skin Applications. Journal of Biomedical Sciences, 3(6), 1–12. https://sarcouncil.com/2024/12/modified-polymeric-surface-liposomal-vitamin-c-as-an-advanced-and-effective-formulation-in-topical-skin-applications
