LIPONOL® XTEND: Boosting Delivery, Stability, and Skin Benefit
What Is LIPONOL® XTEND?
LIPONOL® XTEND is a vesicular delivery system in which retinol (or its esters) is encapsulated within phospholipid bilayers (single or multilamellar).
-
Role of the liposome core: shields retinol from oxidation, light, and degradation, improving its stability and bioavailability.
-
Role of the lipid membrane: enables controlled release, enhances skin interaction, and reduces irritancy by gradual delivery.
This design makes LIPONOL® XTEND both a protective carrier and an effective vehicle for sustained skin delivery.
Effects on Skin Hydration, Barrier & Anti-Aging
1. Moisture Profiling & Skin Comfort
The liposomal system helps maintain stratum corneum hydration by reducing transepidermal water loss (TEWL) and supporting barrier integrity, which in turn supports a more supple skin texture.
2. Barrier Modulation & Elasticity
By integrating with skin lipids and softening them, LIPONOL® XTEND enhances barrier flexibility and elasticity, contributing to smoother, more resilient skin.
3. Enhanced Penetration & Retention
Liposomal encapsulation loosens lipid packing and enhances partitioning of retinol into epidermal and upper dermal layers. Studies show higher retention and deeper delivery compared to conventional retinol creams or solutions.
Research Insights
Enhanced Skin Penetration: LIPONOL® XTEND delivers a higher total amount of retinol into the skin compared to bare retinol at equivalent concentrations.
-
Deeper Layer Distribution: Greater accumulation is observed in the epidermis/dermis, indicating improved transport beyond the stratum corneum barrier.
-
Controlled Release: The increased reservoir fraction in liposomal formulations suggests a sustained-release effect, maintaining retinol availability over time.
-
Concentration-Dependent Effect: As the retinol concentration increases from 0.075% to 0.3%, the delivery efficiency of the liposomal system rises proportionally, showing strong dose responsiveness.
-
Improved Bioavailability: The enhanced penetration and retention profile imply higher bioavailability and potential for superior biological activity (e.g., collagen stimulation, cell renewal).
Conclusion
LIPONOL® XTEND markedly improves its skin penetration efficiency, reservoir formation, and overall retention compared to bare retinol. These findings highlight the superior efficacy and stability of liposomal retinol systems for dermal applications, supporting their use in advanced cosmetic and dermatological formulations aimed at enhanced anti-aging and skin renewal performance.
Reference:
Jun, S.-H., Kim, H., Lee, H., Song, J. E., Park, S. G., & Kang, N.-G. (2021). Synthesis of Retinol-Loaded Lipid Nanocarrier via Vacuum Emulsification to Improve Topical Skin Delivery. Polymers, 13(5), 826. https://doi.org/10.3390/polym13050826
Małgorzata Pawłowska, Marzec, M., Jankowiak, W., & Nowak, I. (2024). Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18—Optimization, Characterization, and Cosmetic Application. International Journal of Molecular Sciences, 25(18), 10078–10078. https://doi.org/10.3390/ijms251810078
Stabilization of Retinol through Incorporation into Liposomes. (2002). BMB Reports, 35(4), 358–363. https://doi.org/10.5483/bmbrep.2002.35.4.358
