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Vitamin E

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Vitamin E is a lipid-soluble antioxidant present mainly as α-tocopherol in human skin. Topically, it scavenges UV-induced reactive oxygen species, prevents lipid peroxidation, and stabilizes cell membranes. It also downregulates pro-inflammatory mediators (PGE2, nitric oxide) and modulates collagen, glycosaminoglycan, and pigment pathways. While widely used in dermatology and cosmetics, its efficacy is limited by formulation stability and the lack of well-controlled clinical trials.

Vitamin E

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FEATURES AND KIENTICS

Lipid-soluble, membrane-stabilizing, and photoprotective

Vitamin E is a fat-soluble antioxidant that integrates into cell membranes, protecting them from lipid peroxidation and UV-induced oxidative stress. Its gradual release within the skin provides anti-inflammatory, reparative, and photoprotective benefits, though stability depends on formulation against air and light exposure.

Lipid-soluble
Membrane stabilizer
Photoprotective
Stratum corneum reservoir
Stabilized forms
Ester derivatives improve stability
Product Features

Mechanism of Action

1
Free Radical Scavenging: Neutralizes reactive oxygen species (ROS) generated by UV exposure, preventing lipid peroxidation in skin cell membranes.
2
Anti-inflammatory Pathway: Inhibits cyclooxygenase activity, reducing prostaglandin E2 and nitric oxide production, thus limiting UV-induced inflammation.
3
Photoprotective/Immunomodulatory Role: Prevents DNA damage, sunburn cell formation, and UV-induced immunosuppression, thereby reducing long-term photoaging and potential tumor formation.
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