Technology Behind
LIPONOL® XTEND is an advanced retinol delivery system featuring polymer-coated vesicles specifically designed to modify the stratum corneum, enhancing skin permeation and significantly extending the retention of retinol within the skin. This multilayered approach ensures optimal delivery and sustained activity of retinol for visible skin improvement.
It stimulates fibroblast activity to boost collagen production, improving skin elasticity and reducing the appearance of fine lines and wrinkles. Additionally, it promotes angiogenesis, supporting skin renewal and maintaining a healthy, revitalized complexion. By inhibiting collagenase and matrix metalloproteinases (MMPs), it also helps preserve the extracellular matrix, enhancing collagen type I and glycosaminoglycan (GAG) synthesis for firmer, deeply hydrated skin. These synergistic effects position LIPONOL® XTEND as a high-performance solution for anti-aging and skin-rejuvenation treatments.
Mechanism of Action
LIPONOL® XTEND enhances skin performance through a combination of advanced mechanisms made possible by its polymer-coated vesicle system. This technology modifies the structure of the stratum corneum, allowing for deeper penetration of retinol and prolonged retention within the skin, ensuring sustained activity and effectiveness.
It actively stimulates fibroblast function, leading to increased collagen production and improved skin elasticity. At the same time, it promotes angiogenesis, which supports skin renewal and boosts overall skin vitality. By inhibiting collagenase and matrix metalloproteinase (MMP) expression, LIPONOL® XTEND further enhances the synthesis of collagen type I and glycosaminoglycans (GAGs), resulting in firmer, more hydrated, and youthful-looking skin.
Prolonged Skin Retention
Offers superior skin retention, ensuring prolonged activity of the active ingredient within the skin layers.
Enhanced Dermal Permeation
Delivers deeper and more effective absorption through the stratum corneum.
Superior Delivery Performance
Demonstrates 2.2-fold greater permeation compared to conventional liposomal formulations.
Pharmacokinetics
Skin Permeation Performance
LIPONOL® XTEND utilizes a polymer-coated vesicle system to significantly enhance the skin permeation of retinol compared to conventional formulations.
Following topical application, the total amount of retinol delivered into the skin using LIPONOL® XTEND was approximately 2.2-fold higher (0.23 ± 2.86 µg) than that achieved with conventional liposomal retinol (0.09 ± 1.29 µg), demonstrating its superior delivery efficiency and deeper skin penetration.
No chart data available for this technology.
